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WERMER SYNDROME
Descriptors Found:
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DeCS
Descriptor
English
:
Multiple Endocrine Neoplasia Type 1
Descriptor
Spanish
:
Neoplasia Endocrina Múltiple Tipo 1
Descriptor
Portuguese
:
Neoplasia Endócrina Múltipla Tipo 1
Synonyms
English
:
MEN 1
Neoplasia, Multiple Endocrine Type 1
Neoplasms, Multiple Endocrine Type 1
Wermer Syndrome
Tree Number:
C04.588.322.400.500
C04.651.600.500
C04.700.630.500
C16.320.700.630.500
C19.344.400.500
Definition
English
:
A form of
multiple endocrine neoplasia
that is characterized by the combined occurrence of tumors in the
PARATHYROID GLANDS
, the
PITUITARY GLAND
, and the PANCREATIC ISLETS. The resulting clinical
signs
include
HYPERPARATHYROIDISM
;
HYPERCALCEMIA
;
HYPERPROLACTINEMIA
; CUSHING
DISEASE
;
GASTRINOMA
; and
ZOLLINGER-ELLISON SYNDROME
. This
disease
is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Indexing Annotation
English
:
coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
History Note
English
:
95; MEA I, MEN I, & WERMER SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Allowable Qualifiers
English
:
blood
blood supply
cerebrospinal fluid
chemistry
chemically induced
classification
congenital
complications
diet therapy
diagnosis
drug therapy
economics
ethnology
embryology
enzymology
epidemiology
etiology
genetics
history
immunology
metabolism
microbiology
mortality
nursing
pathology
prevention & control
physiopathology
parasitology
psychology
radiography
rehabilitation
radionuclide imaging
radiotherapy
secondary
secretion
surgery
therapy
ultrastructure
urine
ultrasonography
veterinary
virology
Record Number:
32134
Unique Identifier:
D018761
Occurrence in VHL
:
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